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323,324,325,326 In a prospective, multicenter, single-blind, phase 2 clinical trial including 41 COVID-19 patients from Wuhan, China, compared with patients in the placebo group ( n = 21), those in the ruxolitinib group ( n = 20) exhibited remarkably reduced levels of seven cytokines, as well as a faster rate of clinical improvement and lymphocyte-count recovery